The benchmark BSE Sensex fell 49 points in early trade on Tuesday, weighed down by losses in healthcare, IT and consumer durables, amid a weak trend in Asian markets.
The 30-share index fell 48.84 points, or 0.19 per cent, to 24,917.56.
The gauge had lost 371.16 points in the previous session.
On similar lines, NSE Nifty edged lower by 13 points, or 0.17 per cent, to 7,602.10.
Brokers said profit-booking in recent gainers and a weak movement at other Asian markets as investors awaited a speech by US Federal Reserve Chair Janet Yellen later in the day, triggered selling.